Active Fluctuations of Microtubule Networks Facilitate Faster Motility of Dynein
نویسندگان
چکیده
منابع مشابه
The role of dynein in microtubule-based motility.
Dyneins are high molecular weight ATPases that function as microtubule-based molecular motors. The axonemal dyneins, discovered 30 years ago, are responsible for the beating movement of cilia and sperm flagella, which they generate by producing sliding between adjacent microtubules. Cytoplasmic dynein, more recently discovered, is involved in diverse activities, including intracellular transpor...
متن کاملSlow axonemal dynein e facilitates the motility of faster dynein c.
We highly purified the Chlamydomonas inner-arm dyneins e and c, considered to be single-headed subspecies. These two dyneins reside side-by-side along the peripheral doublet microtubules of the flagellum. Electron microscopic observations and single particle analysis showed that the head domains of these two dyneins were similar, whereas the tail domain of dynein e was short and bent in contras...
متن کاملActive contraction of microtubule networks
Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large-scale behaviors of these systems. Here, we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can fo...
متن کاملCombinatorial regulation of the balance between dynein microtubule end accumulation and initiation of directed motility
Cytoplasmic dynein is involved in a multitude of essential cellular functions. Dynein's activity is controlled by the combinatorial action of several regulatory proteins. The molecular mechanism of this regulation is still poorly understood. Using purified proteins, we reconstitute the regulation of the human dynein complex by three prominent regulators on dynamic microtubules in the presence o...
متن کاملACCEPTED MANUSCRIPT Active contraction of microtubule networks
Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large scale behaviors of these systems. Here we inves5 tigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can f...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.870